FGFR3 Protein (Dimer, glycosylated, Soluble) (Fc Tag)

N° du produit ABIN1589735

Détail du produit

Antigène: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: Dimer, glycosylated, Soluble

Origine: Humain

Source: Cellules d'insectes

Purification/Conjugué: Cette FGFR3 protéine est marqué à la Fc Tag.

Fonction: FGFR-3(IIIc)/Fc Chimera, soluble

Séquence: ESLGTEQRVV GRAAEVPGPE PGQQEQLVFG SGDAVELSCP PPGGGPMGPT VWVKDGTGLV PSERVLVGPQ RLQVLNASHE DSGAYSCRQR LTQRVLCHFS VRVTDAPSSG DDEDGEDEAE DTGVDTGAPY WTRPERMDKK LLAVPAANTV RFRCPAAGNP TPSISWLKNG REFRGEHRIG GIKLRHQQWS LVMESVVPSD RGNYTCVVEN KFGSIRQTYT LDVLERSPHR PILQAGLPAN QTAVLGSDVE FHCKVYSDAQ PHIQWLKHVE VNGSKVGPDG TPYVTVLKTA GANTTDKELE VLSLHNVTFE DAGEYTCLAG NSIGFSHHSA WLVVLPAEEE LVEADEAGDP RRASIEGRGD PEEPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGK

Specificité: Chromosomal location:4p16.3

Attributs du produit: Length (aa):593

Pureté: > 90 % by SDS-PAGE

Information d'application

Indications d'application: Measured by its binding ability to FGF-2 in a functional ELISA. Recombinant human soluble FGFR-3(IIIc)/Fc Chimera binds to immobilized recombinant human FGF-2 (ABIN1589672).

Commentaires:

Soluble Receptors

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: The lyophilized sFGFR-3/Fc is soluble in water and most aqueous buffers and should be reconstituted in PBS or medium to a concentration not lower than 50 μg/mL.

Buffer: PBS

Stock: -20 °C,-80 °C

Stockage commentaire: Lyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted sFGFR-3/Fc should be stored in working aliquots at -20°C.

Date de péremption: 6 months

Détail du antigène

Antigène: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Autre désignation: FGFR-3 (FGFR3 Produits)

Synonymes: FGFR3 Protein, LOC100034114 Protein, ACH Protein, CD333 Protein, CEK2 Protein, HSFGFR3EX Protein, JTK4 Protein, FR3 Protein, Fgfr-3 Protein, Flg-2 Protein, HBGFR Protein, Mfr3 Protein, sam3 Protein, fc27h01 Protein, wu:fc27h01 Protein, fibroblast growth factor receptor 3 Protein, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) S homeolog Protein, FGFR3 Protein, fgfr3.S Protein, Fgfr3 Protein, fgfr3 Protein

Sujet: Recombinant human soluble FGFR-3 alpha (IIIc) was fused via a Xa cleavage site with the Fc part of human IgG1. Human recombinant soluble FGFR-3 alpha (IIIc)/Fc is a disulfide-linked heterodimeric protein. In the reduced form the glycosylated subunits of sFGFR-3 alpha/human Fc chimera display a molecular mass of 80-85 kDa.Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorigenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGFR-1 to -4 are known. Multiple forms of FGFR-1 to -3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the ß isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). A IIIa isoform which is a secreted FGF binding protein containing only the N-terminal half of the IgIII domain plus some intron sequences has also been reported for FGFR-1. Mutations in FGFR-1 to -3 have been found in patients with birth defects involving craniosynostosis.
Synonyms: FGFR3, ACH, CEK2, JTK4, CD333, HSFGFR3EX

Poids moléculaire: 65.1 kDa

ID gène: 2261

NCBI Accession: NM_000142, NP_000133

UniProt: P22607

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding