Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

Podoplanin Protein (PDPN) (Soluble) (His tag)

PDPN Origine: Rat Hôte: Escherichia coli (E. coli) Recombinant > 98 % by SDS-PAGE
N° du produit ABIN1589761
  • Antigène Voir toutes Podoplanin (PDPN) Protéines
    Podoplanin (PDPN)
    Type de proteíne
    Recombinant
    Attributs du protein
    Soluble
    Origine
    • 12
    • 9
    • 3
    • 2
    • 1
    • 1
    Rat
    Source
    • 11
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette Podoplanin protéine est marqué à la His tag.
    Fonction
    Podoplanin, soluble
    Séquence
    GAIGALEDDL VTPGPGDDMV NPGLEDRIET TDTTGELDKS TAKAPLVPTQ PPIEELPTSG TSDHDHKEHE STTTVKAVTS HSTDKKTTHP NRDNAGGETQ TTDKKDGLAV VTLEHHHHHH
    Specificité
    Chromosomal location:5q36
    Attributs du produit
    Length (aa):120
    Pureté
    > 98 % by SDS-PAGE
    Top Product
    Discover our top product PDPN Protéine
  • Commentaires

    Soluble Receptors

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    We recommend a quick spin followed by reconstitution in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20 °C for future use.
    Buffer
    0.5X PBS
    Conseil sur la manipulation
    Centrifuge vial prior to opening.
    Stock
    RT,-20 °C
    Stockage commentaire
    The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted sPodoplanin should be stored in working aliquots at -20°C.
  • Antigène
    Podoplanin (PDPN)
    Autre désignation
    Podoplanin (PDPN Produits)
    Synonymes
    PDPN Protein, AGGRUS Protein, GP36 Protein, GP40 Protein, Gp38 Protein, HT1A-1 Protein, OTS8 Protein, PA2.26 Protein, T1A Protein, T1A-2 Protein, OTS-8 Protein, RANDAM-2 Protein, T1-alpha Protein, T1a Protein, T1alpha Protein, E11 Protein, RTI40 Protein, podoplanin Protein, PDPN Protein, Pdpn Protein
    Sujet
    Podoplanin, also known as glycoprotein 38 (gp38), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 38 kDa type I transmembrane sialoglycoprotein and member of the podoplanin family. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. The ECD contains abundant Ser/Thr residues as potential sites for Oglycosylation, and the cytoplasmic region contains putative sites for kinase C and cAMP phosphorylation. Mouse Podoplanin shares 77% and 46 % aa sequence identity with rat and human Podoplanin, respectively. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and on numerous tumors including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for Ctype lectin like receptor 2 (CLEC2). Their association is dependent on sialic acid on Oglycans of Podoplanin. Through its association with CLEC2, Podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.
    Synonyms: Pdpn, E11, Gp38, OTS-8, RTI40, T1-alpha
    ID gène
    54320
    NCBI Accession
    NM_019358, NP_062231
    UniProt
    Q64294
    Pathways
    Dicarboxylic Acid Transport
Vous êtes ici:
Support technique