CCM2 Protein (His tag)

N° du produit ABIN1589765

Détail du produit

Antigène: CCM2 (Cerebral Cavernous Malformation 2 (CCM2))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette CCM2 protéine est marqué à la His tag.

Fonction: CCM-2

Séquence: MGSSHHHHHH SSGLVPRGSH MEEEGKKGKK PGIVSPFKRV FLKGEKSRDK KAHEKVTERR PLHTVVLSLP ERVEPDRLLS DYIEKEVKYL GQLTSIPGYL NPSSRTEILH FIDNAKRAHQ LPGHLTQEHD AVLSLSAYNV KLAWRDGEDI ILRVPIHDIA AVSYVRDDAA HLVVLKTAQD PGISPSQSLC AESSRGLSAG SLSESAVGPV EACCLVILAA ESKVAAEELC CLLGQVFQVV YTESTIDFLD RAIFDGASTP THHLSLHSDD SSTKVDIKET YEVEASTFCF PESVDVGGAS PHSKTISESE LSASATELLQ DYMLTLRTKL SSQEIQQFAA LLHEYRNGAS IHEFCINLRQ LYGDSRKFLL LGLRPFIPEK DSQHFENFLE TIGVKDGRGI ITDSFGRHRR ALSTTSSSTT NGNRATGSSD DRSAPSEGDE WDRMISDISS DIEALGCSMD QDSA

Specificité: Chromosomal location:7p13

Attributs du produit: Length (aa):464

Pureté: > 95 % by SDS-PAGE

Information d'application

Commentaires:

Cytokines & Growth Factors

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS

Stock: 4 °C,-20 °C

Stockage commentaire: Store human CCM2 at -20°C. It can be stored at 4°C for a limited period of time of 7 days.

Détail du antigène

Antigène: CCM2 (Cerebral Cavernous Malformation 2 (CCM2))

Autre désignation: CCM-2 (CCM2 Produits)

Synonymes: C7orf22 Protein, OSM Protein, malcavernin Protein, CCM2 Protein, BC029157 Protein, TUF2 Protein, vtn Protein, zgc:110233 Protein, CCM2 scaffolding protein Protein, cerebral cavernous malformation 2 Protein, malcavernin Protein, CCM2 Protein, Ccm2 Protein, LOC100304744 Protein, ccm2 Protein

Sujet: Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke. Familial CCM is caused by mutations in KRIT1 (CCM1) or in malcavernin (CCM2). The roles of the CCM proteins in the pathogenesis of the disorder remain largely unknown. It was shown that the CCM1 gene product, KRIT1, interacts with the CCM2 gene product, malcavernin. Analogous to the established interactions of CCM1 and beta1 integrin with ICAP1, the CCM1/CCM2 association is dependent upon the phosphotyrosine binding (PTB) domain of CCM2. A familial CCM2 missense mutation abrogates the CCM1/CCM2 interaction, suggesting that loss of this interaction may be critical in CCM pathogenesis. CCM2 and ICAP1 bound to CCM1 via their respective PTB domains differentially influence the subcellular localization of CCM1. The data indicate that the genetic heterogeneity observed in familial CCM may reflect mutation of different molecular members of a coordinated signaling complex. The CCM-2 is fused to a N-terminal His-tag (6x His).
Synonyms: CCM-2, malcavernin, cerebral cavernous malformation 2, OSM, C7orf22, PP10187

Poids moléculaire: 51.0 kDa

ID gène: 83605

NCBI Accession: NM_001029835, NP_001025006

UniProt: Q9BSQ5

Pathways: Cell-Cell Junction Organization