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VEGF206 Protein (Homodimer)

Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 98 % by SDS-PAGE Active
N° du produit ABIN1589790
  • Antigène Tous les produits VEGF206
    VEGF206 (Vascular Endothelial Growth Factor 206 (VEGF206))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    Homodimer
    Origine
    Humain
    Source
    Escherichia coli (E. coli)
    Fonction
    VEGF206
    Séquence
    APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQEKKSVRG KGKGQKRKRK KSRYKSWSVY VGARCCLMPW SLPGPHPCGP CSERRKHLFV QDPQTCKCSC KNTDSRCKAR QLELNERTCR CDKPRR
    Specificité
    Chromosomal location:6p12
    Attributs du produit
    Length (aa):206
    Pureté
    > 98 % by SDS-PAGE
  • Indications d'application
    The ED50 for stimulation of cell proliferation in human dermal lymphatic endothelial cells (HDLEC) by VEGF206 has been determined to be in the range of 5-15 ng/mL.
    Commentaires

    Cytokines & Growth Factors

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    The lyophilized VEGF206 should be reconstituted in 50 mM acetic acid to a concentration not lower than 50 μg/mL. For long term storage we recommend to add at least 0.1 % human or bovine serum albumin.
    Buffer
    50 mM acetic acid
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    RT,-20 °C
    Stockage commentaire
    The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted VEGF206 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
  • Antigène
    VEGF206 (Vascular Endothelial Growth Factor 206 (VEGF206))
    Abstract
    VEGF206 Produits
    Sujet
    Vascular endothelial growth factor-A (VEGF-A) mRNA undergoes alternative splicing events that generate several different homodimeric isoforms, e.g. VEGF121, VEGF145, VEGF165, VEGF189, and VEGF206. VEGF121 is a non-heparin-binding acidic protein, which is freely diffusible. The longer forms, VEGF189 or VEGF206, are highly basic proteins tightly bound to extracellular heparin-containing proteoglycans. VEGF165 has intermediate properties. VEGF165 was observed largely in Golgi apparatus-like structures. Immunogold labeling of cells expressing VEGF189 or VEGF206 revealed that the staining was localized to the subepithelial ECM. VEGF associated with the ECM was bioactive, because endothelial cells cultured on ECM derived from cells expressing VEGF189 or VEGF2O6 were markedly stimulated to proliferate. In addition, ECM-bound VEGF can be released into a soluble and bioactive form by heparin or plasmin. ECM-bound VEGF189 and VEGF206 have molecular masses consistent with the intact polypeptides. The ECM may represent an important source of VEGF and angiogenic potential. The isoforms VEGF145, VEGF165 and VEGF189 bind to heparin with high affinity, the affinity of VEGF206 is much weaker. All dimeric forms have similar biological activities but their bio­availability is very different. However so far there are only a few data about the biological activities of VEGF206.
    Synonyms: Vascular endothelial growth factor A, VEGFA,VPF, VEGF, MVCD2
    Poids moléculaire
    approx. 47 kDa (Dimer)
    ID gène
    7422
    NCBI Accession
    NM_001025366, NP_001020537
    UniProt
    P15692
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