IL1R1 Protein (C-Term, Extracellular Domain)

N° du produit ABIN1684651

Détail du produit

Antigène: IL1R1 (Interleukin 1 Receptor, Type I (IL1R1))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: C-Term, Extracellular Domain

Origine: Souris

Source: HEK-293T Cells

Specificité: Optimized DNA sequence encoding Human extracellular domain of mouse IL-1 receptor type 1 including a C-terminal His tag was expressed in HEK293 cells.

Attributs du produit: Recombinant IL-R1 (CD121a) is a protein consisting of 330 amino acid residue subunits, due to glycosylation migrates as an approximately 55-60 kDa protein on SDS-PAGE.

Pureté: > 97 %, as determined by SDS-PAGE and HPLC

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).

Information d'application

Commentaires:

Recombinant mouse IL1R1 activity was measured by its ability to bind mouse IL1B in a functional ELISA. Immobilized mouse IL1A at 10 µg/mL (100 µL/well) can bind mouse IL1R1, The EC50 of mouse IL1R1 is 0.13 µg/mL.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS solution, pH 7.2, 5 % Trehalose.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: The lyophilized protein is stable for at least years from date of receipt at -20 °C. Upon reconstitution, this cytokine can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months, with a carrier protein without detectable loss of activity.

Date de péremption: 12-24 months

Détail du antigène

Antigène: IL1R1 (Interleukin 1 Receptor, Type I (IL1R1))

Autre désignation: CD121a (IL1R1 Produits)

Synonymes: CD121A Protein, D2S1473 Protein, IL-1R-alpha Protein, IL1R Protein, IL1RA Protein, P80 Protein, CD121a Protein, CD121b Protein, IL-iR Protein, Il1r-1 Protein, DER4 Protein, Fit-1 Protein, Ly84 Protein, ST2L Protein, St2 Protein, St2-rs1 Protein, T1 Protein, T1/ST2 Protein, interleukin 1 receptor type 1 Protein, interleukin 1 receptor, type I Protein, interleukin 1 receptor-like 1 Protein, IL1R1 Protein, Il1r1 Protein, Il1rl1 Protein

Sujet: Eotaxin belongs to the platelet factor-4 family of chemokines. The gene symbol is SCYA11. The factor is being referred to also as Eotaxin-1 and has been renamed CCL11. Eotaxin induces substantial accumulation of eosinophils in the skin without significantly affecting the accumulation of neutrophils. Eotaxin is a potent stimulator of both guinea pig and human eosinophils in vitro. The Eotaxin receptor is a G-protein-coupled receptor selectively expressed in human eosinophils.

UniProt: P13504

Pathways: Signalisation NF-kappaB, Carbohydrate Homeostasis, Cancer Immune Checkpoints