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HSPD1 Protein (partial)

HSPD1 Origine: Bactéries Hôte: Escherichia coli (E. coli) Recombinant >90% WB, SDS, ELISA, Func
N° du produit ABIN1686691
  • Antigène Voir toutes HSPD1 Protéines
    HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))
    Type de proteíne
    Recombinant
    Attributs du protein
    partial
    Origine
    • 8
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Bactéries
    Source
    • 15
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Application
    Western Blotting (WB), SDS-PAGE (SDS), ELISA, Functional Studies (Func)
    Séquence
    EDPYEKIGAE LVKEVAKKTD DVAGDGTTTA TVLAQALVRE GLRNVAAGAN PLGLKRGIEK AVEKVTETLL KGAKEVETKE QIAATAAISA GDQSIGDLIA EAMDKVGNEG VITVEESNTF GLQLELTEGM RFDKGYISGY FVTDPERQEA VLEDPYILLV SSKVSTVKDL LPLXXXXXXX GKPLLIIAED VEGEALSTLV
    Specificité
    ~65 kDa
    Purification
    Multi-Step Purified
    Pureté
    >90%
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Commentaires

    This product has been certified >90% pure using SDS-PAGE analysis.

    Restrictions
    For Research Use only
  • Concentration
    Lot specific
    Buffer
    10 mM Tris pH 8, 105 mM NaCl, 5 mM EDTA
    Stock
    -20 °C
  • Sun, Shen, Liu, Tan, Tian, Luo, Lai, Dai, Guo: "Heat shock protein 65 promotes atherosclerosis through impairing the properties of high density lipoprotein." dans: Atherosclerosis, Vol. 237, Issue 2, pp. 853-61, (2014) (PubMed).

    Adamus, Bonnah, Brown, David: "Detection of autoantibodies against heat shock proteins and collapsin response mediator proteins in autoimmune retinopathy." dans: BMC ophthalmology, Vol. 13, pp. 48, (2013) (PubMed).

  • Antigène
    HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))
    Abstract
    HSPD1 Produits
    Sujet
    HSP65 isolated from Mycobacterium bovis BCG, is a member of the HSP60 family of heat shock proteins (2, 3). HSP60s are mitochondrial chaperonins that are typically held responsible for the transportation and refolding of proteins from the cytoplasm into the mitochondrial matrix. In addition to its role as a heat shock protein, HSP60 functions as a chaperonin to assist in folding linear amino acid chains into their respective three-dimensional structure. HSP60s are a ubiquitous class of HSPs that specifically promote the folding and assembly of cellular polypeptides in an ATP-dependent manner (1). Specifically, sequence comparison of HSP65 from different mycobacterium strains showed that the protein sequence of M. bovis BCG is identical to that of M. tuberculosis, and very similar to that of M. leprae, the pathogens that cause tuberculosis and tuberculoid leprosy, respectively (2,4). Mycobacterium bovis BCG HSP65 was identified as the immunodominant antigen during mycobacterial diseases and vaccination. It is also believed to be the antigen that induces autoimmune disease, such as adjuvant arthritis in rats (5, 6).
    Poids moléculaire
    approx. 65 kDa
    UniProt
    Q1EHB9
    Pathways
    Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
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