IL-13 Protein (AA 26-131) (His tag)
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- Antigène Voir toutes IL-13 (IL13) Protéines
- IL-13 (IL13) (Interleukin 13 (IL13))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 26-131
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Origine
- Souris
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Source
- Human Cells
- Purification/Conjugué
- Cette IL-13 protéine est marqué à la His tag.
- Fonction
- Recombinant Mouse Interleukin-13/IL-13 (Ser26-Phe131,C-6His)
- Séquence
- SVSLPLTLKE LIEELSNITQ DQTPLCNGSM VWSVDLAAGG FCVALDSLTN ISNCNAIYRT QRILHGLCNR KAPTTVSSLP DTKIEVAHFI TKLLSYTKQL FRHGPFVDHH HHHH
- Attributs du produit
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Recombinant Mouse Interleukin-13/IL-13 (Ser26-Phe131,C-6His)
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- Stérilité
- 0.2 μm filtered
- niveau d'endotoxine
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product IL13 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Conseil sur la manipulation
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- Stock
- 4 °C/-20 °C/-80 °C
- Stockage commentaire
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- IL-13 (IL13) (Interleukin 13 (IL13))
- Autre désignation
- Interleukin-13/IL-13 (IL13 Produits)
- Synonymes
- IL13 Protein, IL-13 Protein, P600 Protein, Il-13 Protein, L13 Protein, interleukin 13 Protein, IL13 Protein, Il13 Protein
- Sujet
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Recombinant Mouse Interleukin-13/IL-13 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Ser26-Phe131) of Mouse IL-13 fused with a polyhistidine tag at the C-terminus.
Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58 % sequence identity with human protein and exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13Rα1 with low affinity and triggers association of IL4Rα, generating a high affinity heterodimeric receptor IL13R and eliciting downstream signals. IL13 also binds IL-13Rα2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease. - Poids moléculaire
- 12.7 kDa
- UniProt
- P20109
- Pathways
- Signalistation JAK/STAT, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport
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