IFN alpha 2b Protéine

N° du produit ABIN1880391

Détail du produit

Antigène: IFN alpha 2b

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 95 % by SDS-PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with sterile 18 mΩ/cm^3 H2O.

Buffer: 10 mM Phosphate buffer and 200 mM NaCl (pH 7.0)

Agent conservateur: Without preservative

Stock: 4 °C

Détail du antigène

Antigène: IFN alpha 2b

Abstract: IFN alpha 2b Produits

Synonymes: IFN-alphaA Protein, IFNA Protein, IFNA2B Protein, INFA2 Protein, interferon alpha 2 Protein, IFNA2 Protein

Sujet: IFN-alpha, a multifunctional cytokine important in the innate immune system, has been proposed to play a major pathogenic role in the development of systemic lupus erythematosus in humans and mice. IFNA bound complement component receptor-2 (CR2) in the same affinity range as other CR2 ligands. Asokan et al. (2006) proposed that the roles of CR2 and IFNA in development of autoimmunity may be mechanistically linked to pathogenesis of systemic lupus erythematosus. Interferon-alpha and -beta (IFN-alpha/beta) and the tumour suppressor p53 are essential for the induction of apoptosis in cancerous cells and in antiviral immune responses, respectively. The transcription of the p53 gene is induced by IFN-alpha/beta, accompanied by an increase in p53 protein level. IFN-alpha/beta signalling itself does not activate p53, rather, it contributes to boosting p53 responses to stress signals.

Poids moléculaire: 19.2 +/- 1.9 kDa