CNTF Protein (AA 1-200)

N° du produit ABIN2017718

Détail du produit

Antigène: CNTF (Ciliary Neurotrophic Factor (CNTF))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 1-200

Origine: Humain

Source: HEK-293T Cells

Attributs du produit: ED50 < 0.20 μg/mL, measured in a cell proliferation assay using TF-1 cells.

Pureté: > 95 % as analyzed by SDS-PAGE.

niveau d'endotoxine: < 0.2 EU/μg, determined by LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Stock: -80 °C

Stockage commentaire: Lyophilized recombinant Human Ciliary Neurotrophic Factor (CNTF) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human Ciliary Neurotrophic Factor (CNTF) should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Date de péremption: 6 months

Détail du antigène

Antigène: CNTF (Ciliary Neurotrophic Factor (CNTF))

Abstract: CNTF Produits

Synonymes: GPA Protein, CNTF Protein, HCNTF Protein, AI429687 Protein, ciliary neurotrophic factor Protein, CNTF Protein, Cntf Protein

Sujet: Ciliary neurotrophic factor (CNTF) is a polypeptide initially purified from chick embryo ocular tissue and identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture. Subsequent studies have demonstrated that CNTF is a survival factor for additional neuronal cell types including: dorsal root ganglion sensory neurons, sympathetic ganglion neurons, embryonic motor neurons, major pelvic ganglion neurons and hippocampal neurons. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. The gene for human CNTF has been localized to the proximal region of the long arm of chromosome 11. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83 % homology in their protein sequence. CNTF is structurally related to IL-6, IL-11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal-transducing subunit in their receptor complexes.
Synonyms: Ciliary Neurotrophic Factor

Poids moléculaire: 22-28 kDa, observed by reducing SDS-PAGE.

UniProt: P26441

Pathways: Signalistation JAK/STAT