FGF18 Protein (AA 28-199)

N° du produit ABIN2017814

Détail du produit

Antigène: FGF18 (Fibroblast Growth Factor 18 (FGF18))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 28-199

Origine: Rat

Source: Escherichia coli (E. coli)

Attributs du produit: ED50 < 0.5 xg/mL, measured by a cell proliferation assay using 3T3 cells, corresponding to a specific activity of > 2x 10^3 units/mg.

Pureté: > 95 % as analyzed by SDS-PAGE and HPLC.

niveau d'endotoxine: < 0.2 EU/μg, determined by LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Stock: -80 °C

Stockage commentaire: Lyophilized recombinant rat Fibroblast Growth Factor 18 (rrFGF-18) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rrFGF-18 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

Date de péremption: 6 months

Détail du antigène

Antigène: FGF18 (Fibroblast Growth Factor 18 (FGF18))

Autre désignation: Fibroblast Growth Factor-18 (FGF-18) (FGF18 Produits)

Synonymes: FGF-18 Protein, ZFGF5 Protein, D130055P09Rik Protein, fgf18 Protein, FGF18 Protein, fgf18l Protein, fibroblast growth factor 18 Protein, fibroblast growth factor 18a Protein, fibroblast growth factor 18b Protein, FGF18 Protein, Fgf18 Protein, fgf18a Protein, Tsp_09844 Protein, fgf18b Protein

Sujet: Fibroblast Growth Factor 18 (FGF-18) is a pleiotropic cytokine belonging to the heparin-binding FGF family, which has 23 different members. Structurally, FGF-18 is closely related to FGF-8 and FGF-17. Like other FGFs, FGF-18 can bind to different FGF receptors in vivo. FGF-18 is expressed in various tissues and has multiple functions: during long bone growth, FGF-18 is expressed in perichondrium and developing joints, and regulates bone formation by inhibiting chondrocyte proliferation and differentiation, FGF-18 knock-out mice survive embryonic development, but exhibit skeletal abnormalities and die in the early neonatal period. FGF-18 also induces ectopic cartilage formation in the lung, and alters the morphology of the pulmonary mesenchyma. Recombinant rat Fibroblast Growth Factor 18 (rrFGF-18) produced in E. coli is a single non-glycosylated polypeptide chain containing of 172 amino acids. A fully biologically active molecule, rrFGF-18 has a molecular mass of 20.1 kDa analyzed by non-reducing SDS-PAGE.
Synonyms: Fibroblast growth factor 18, FGF-18, zFGF5, Fgf18, D130055P09Rik

Poids moléculaire: 20.1 kDa, observed by non-reducing SDS-PAGE.

UniProt: O88182

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway