HVEM (TNFRSF14)
(Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))
Type de proteíne
Recombinant
Activité biologique
Active
Attributs du protein
AA 39-184, AA 102-300
Origine
Humain
Source
Insect cells (Sf9)
Purification/Conjugué
Cette HVEM protéine est marqué à la Fc Tag.
Attributs du produit
ED50 < 0.1 μg/mL, measured by the neutralization assay using 929 cells in presence of 0.25 ng/mL of human TNF-beta, corresponding to a specific activity of > 1x10^4 units/mg. AA 39-184, fused with a C-terminal human Fc region AA 102-300
Herpes Virus Entry Mediator (HVEM) is a transmembrane protein that is the receptor for TNFSF14 (also known as LIGHT) and is therefore referred to asTNFRSF14. HVEM is expressed broadly on immune cells such as T cells, natural killer (NK) cells and monocytes. The interaction of 3 Molecules of LIGHT with three molecules of HVEM forms a hexameric complex that leads to the recruitment and retention of effector cells and activates NK cells to produce large amounts of IFN-gamma and GM-CSF. In addition to the canonical binding partner LIGHT, HVEM can also bind to the inhibitory signaling protein, B- and T- lymphocyte attenuator (BTLA),which suppresses immune responses. Therefore, the HVEM network plays an important role in regulating immunity and the behavior of lymphocytes.Recombinant human HVEM-Fc (rhHVEM-Fc) produced in Sf9 insect cells is a single glycosylated polypeptide chain containing 376 amino acids. A fully biologically active molecule, rhHVEM-Fc has a molecular mass of around 45 kDa analyzed by reducing SDS-PAGE. Synonyms: TNFRSF14, TR2