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IL18BP Protein (AA 31-194)

IL18BP Origine: Humain Hôte: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE and HPLC. Active
N° du produit ABIN2018075
  • Antigène Voir toutes IL18BP Protéines
    IL18BP (Interleukin 18 Binding Protein (IL18BP))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 31-194
    Origine
    • 11
    • 4
    • 3
    • 2
    • 1
    Humain
    Source
    • 11
    • 6
    • 1
    • 1
    CHO Cells
    Attributs du produit
    ED50 < 30 ng /mL, measured in a bioassay using KG-1 cells in the presence of 50 ng/mL Human IL-18.
    Pureté
    > 95 % as analyzed by SDS-PAGE and HPLC.
    niveau d'endotoxine
    < 0.2 EU/μg, determined by LAL method.
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    Discover our top product IL18BP Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstituted in ddH2O or PBS at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against PBS.
    Stock
    -80 °C
    Stockage commentaire
    Lyophilized recombinant Human IL-18BP remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human IL-18BP should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
    Date de péremption
    6 months
  • Antigène
    IL18BP (Interleukin 18 Binding Protein (IL18BP))
    Autre désignation
    Interleukin-18 Binding Protein (IL-18 BP) (IL18BP Produits)
    Synonymes
    IL18BP Protein, IL-18BP Protein, Igifbp Protein, MC54L Protein, IL18BPa Protein, interleukin 18 binding protein Protein, IL18BP Protein, Il18bp Protein
    Sujet
    Interleukin-18 binding protein, also known as IL-18BP and tadekinig-alfa, is a secreted glycoprotein that contains an Ig-like C2-type domain. It is expressed in heart, lung, placenta and spleen. IL-18BP functions as an inhibitor of the proinflammatory cytokine IL-18. It binds to IL-18, prevents the binding of IL-18 to its receptor, and thus blocks IL-18-induced IFN-gamma production. The complete Ig domain has been shown to mediate the binding and neutralizing properties. IFN-gamma is able to upregulate the expression of IL-18BP, indicating that IL-18 activity is regulated by a feedback mechanism through IL-18BP.
    Synonyms: Tadekinig-alfa, IL18BP
    Poids moléculaire
    42-44 kDa, observed by reducing SDS-PAGE.
    UniProt
    O95998
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