CCL2 Protein (AA 24-148)

N° du produit ABIN2018224

Détail du produit

Antigène: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 24-148

Origine: Rat

Source: HEK-293T Cells

Attributs du produit: The EC50 value of rat MCP-1/CCL2 on Ca2+ mobilization assay in CHO-K1/G alpha 15/rCCR2 cells (human G alpha 15 and rat CCR2 stably expressed in CHO-K1 cells) is less than 0.3 μg/mL.

Pureté: > 98 % as analyzed by SDS-PAGE.

niveau d'endotoxine: < 0.2 EU/μg, determined by LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Stock: -80 °C

Stockage commentaire: Lyophilized recombinant Rat MCP-1/CCL2 remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Rat MCP-1/CCL2 should be stable up to 1 week at 4 °C or up to 3 months at -20 °C.

Date de péremption: 6 months

Détail du antigène

Antigène: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Autre désignation: MCP-1/CCL2 (CCL2 Produits)

Synonymes: GDCF-2 Protein, HC11 Protein, HSMCR30 Protein, MCAF Protein, MCP-1 Protein, MCP1 Protein, SCYA2 Protein, SMC-CF Protein, AI323594 Protein, JE Protein, Scya2 Protein, Sigje Protein, MCP-1A Protein, MCP1A Protein, C-C motif chemokine ligand 2 Protein, chemokine (C-C motif) ligand 2 Protein, C-C motif chemokine 2 Protein, CCL2 Protein, Ccl2 Protein, LOC101120093 Protein

Sujet: Chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemotactic protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. CCL2 is implicated in the pathogeneses of several diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis and atherosclerosis. CCL2 is anchored in the plasma membrane of endothelial cells by glycosaminoglycan side chains of proteoglycans. CCL2 is primarily secreted by monocytes, macrophages and dendritic cells. CCL2 can signal through the CCR2 receptor.Recombinant rat MCP-1/CCL2 produced in HEK293 cells is a polypeptide chain containing 125 amino acids. A fully biologically active molecule, rrMCP-1/CCL2 has a molecular mass of 10-15 kDa analyzed by reducing SDS-PAGE.
Synonyms: MCP-1, MCAF, JE, Monocyte Chemotactic Protein-1 (MCP-1), CCL2

Poids moléculaire: 10-15 kDa, observed by reducing SDS-PAGE.

UniProt: P14844

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, Phosphorylation & l'infection par le SRAS-CoV-2