Neurotrophin 4 Protein (NTF4) (AA 80-209)
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- Antigène Voir toutes Neurotrophin 4 (NTF4) Protéines
- Neurotrophin 4 (NTF4)
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 80-209
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Origine
- Souris
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Source
- Escherichia coli (E. coli)
- Attributs du produit
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ED50 <1 μg/mL, measured by a cell proliferation assay usingC6cells, corresponding to a specific activity of>1× 10^3 units/mg.
AA 80-209, expressed with an N-terminal Met. - Pureté
- > 95 % by SDS-PAGEanalysis.
- niveau d'endotoxine
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product NTF4 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in 50 mM acetic acid or ddH2O at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against 50 mM acetic acid.
- Stock
- -80 °C
- Stockage commentaire
- Lyophilized recombinant mouse Neurotrophin-4 (rmNT-4) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rmNT-4 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
- Date de péremption
- 6 months
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- Antigène
- Neurotrophin 4 (NTF4)
- Autre désignation
- Neurotrophin-4 (NT-4) (NTF4 Produits)
- Synonymes
- NTF5 Protein, GLC10 Protein, GLC1O Protein, NT-4 Protein, NT-4/5 Protein, NT-5 Protein, NT4 Protein, NT5 Protein, NT4P Protein, Ntf5 Protein, 2900040K06Rik Protein, AI462899 Protein, NT4/5 Protein, Ntf-5 Protein, Ntf4 Protein, neurotrophin 4 Protein, neurotrophin 5 Protein, NTF4 Protein, Ntf4 Protein, ntf4 Protein, Ntf5 Protein
- Sujet
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Neurotrophin-4 (NT-4) is a small secreted cytokine, and belongs to the Neurotrophin (NT) family, which also includes Brain Derived Neurotropic Factor (BDNF), Nerve Growth Factor (NGF), and NT-3. NT family members are all derived from similar sized protein precursors, composed of N-terminal propeptides and C-terminal mature domains, which are separated by posttranslational proteolytic cleavage. NT-4 (along with NT-3) is foundin the brains of mammals . In vivo, NT-4 binds to the common receptor, p75NTR, and a tyrosine kinase receptor, TrkB. The heterotrimeric complex activates the NF-kappaB transcription factor. NT-4 is essential for the differentiation and wiring regulation of the central and peripheral nervous systems during development, and is related to important diseases including Alzheimer's.Recombinant mouse Neurotrophin-4 (rmNT-4) produced in E. coli is a noncovalently linked homodimer containing two non-glycosylated polypeptide chainsof 131 amino acids. A fully biologically active molecule, rmNT-4 has a molecular mass of 14.0 kDaanalyzed by reducing SDS-PAGE.
Synonyms: Neurotrophin-4, Neurotrophic 4/5 (NT-4/NT-5) - Poids moléculaire
- 14.0 kDa, observed by reducing SDS-PAGE.
- UniProt
- Q80VU4
- Pathways
- Signalisation RTK
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