NOG Protein (AA 28-232)

N° du produit ABIN2018291

Détail du produit

Antigène: NOG (Noggin (NOG))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 28-232

Origine: Humain

Source: CHO Cells

Attributs du produit: ED50<2.5 ng/mL, measured in a bioassay using ATDC5 cells in the presence of 10 ng/mL human BMP-4.

Pureté: > 95 % as analyzed by SDS-PAGE.

niveau d'endotoxine: < 0.2 EU/μg, determined by LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Stock: -80 °C

Stockage commentaire: Lyophilized recombinant human Noggin remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, human Nogginshould be stable up to 1 week at 4°C or up to 2 months at -20°C.

Date de péremption: 6 months

Détail du antigène

Antigène: NOG (Noggin (NOG))

Autre désignation: Noggin (NOG Produits)

Sujet: Noggin, also known as NOG, is a homodimeric glycoprotein that bindsto and modulates the activity of TGF-beta family ligands. It is expressed in condensing cartilage and immature chondrocytes. Noggin antagonizes bone morphogenetic protein (BMP) activities by blocking epitopes on BMPs needed for binding to their receptors. Noggin has been shown to be involved in many developmental processes, such as neural tube formation and joint formation. During development, Noggin diffuses through extracellular matrices and forms morphogenic gradients, regulating cellular responses dependent on the local concentration of the signaling molecule.
Synonyms: NOG

Poids moléculaire: 29-31kDa, observed by reducing SDS-PAGE.

UniProt: Q13253

Pathways: Stem Cell Maintenance, Tube Formation