Lyophilized recombinant Human TNF Receptor Type I remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human TNF Receptor Type I should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
Date de péremption
6 months
Antigène
TNFRSF1A
(Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))
TNF Receptor Type I, is also known as TNF R-p55/p60 and TNFRSF1A. It is a type I transmembrane protein member of the TNF receptor superfamily. It is expressed in most cell types. Binding of either TNF-alpha or TNF-beta to TNF-R1 initiates a signal transduction pathway that results in the activation of the transcription factor NF-kappaB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells, induce apoptosis. TNF-R1 is essential for proper development of lymph node germinal centers and Peyer's patches and for combating intracellular pathogens such as Listeria. It is stored in the Golgi and translocates to the cell surface following proinflammatory stimuli. Synonyms: Soluble Tumor Necrosis Factor type I, TNFRSF1A, TNFAR, TNF-R55, TNFR60, p55, CD120a