CD40 Protein (CD40) (AA 21-193) (His tag)
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- Antigène Voir toutes CD40 Protéines
- CD40
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 21-193
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette CD40 protéine est marqué à la His tag.
- Séquence
- AA 21-193
- Attributs du produit
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20 kDa. The protein migrates as 32 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Pureté
- >95 % as determined by SDS-PAGE.
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product CD40 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
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Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist." dans: Journal for immunotherapy of cancer, Vol. 9, Issue 1, (2021) (PubMed).
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Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist." dans: Journal for immunotherapy of cancer, Vol. 9, Issue 1, (2021) (PubMed).
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- Antigène
- CD40
- Autre désignation
- CD40 (CD40 Produits)
- Synonymes
- Bp50 Protein, CDW40 Protein, TNFRSF5 Protein, p50 Protein, AI326936 Protein, GP39 Protein, HIGM1 Protein, IGM Protein, IMD3 Protein, T-BAM Protein, TRAP Protein, Tnfrsf5 Protein, TNFSF5 Protein, CD40 molecule Protein, CD40 antigen Protein, CD40 Protein, Cd40 Protein
- Sujet
- Tumor necrosis factor receptor superfamily member 5 (TNFRSF5) is also known as CD40, is a member of the TNF receptor superfamily. The expression of CD40 is diverse. TNFRSF5 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is the receptor for TNFSF5/CD40LG. Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3).
- Poids moléculaire
- 21.1 kDa
- Pathways
- Signalisation NF-kappaB, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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