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CD47 Protein (CD47) (AA 19-139) (Fc Tag)

CD47 Origine: Humain Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
N° du produit ABIN2180805
  • Antigène Voir toutes CD47 Protéines
    CD47
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 19-139
    Origine
    • 31
    • 14
    • 6
    • 6
    • 4
    • 2
    • 1
    Humain
    Source
    • 41
    • 8
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette CD47 protéine est marqué à la Fc Tag.
    Séquence
    AA 19-139
    Attributs du produit
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.4 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Pureté
    >95 % as determined by SDS-PAGE.
    Stérilité
    0.22 μm filtered
    niveau d'endotoxine
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product CD47 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    50 mM Tris, 100 mM Glycine, pH 7.5
    Conseil sur la manipulation
    Please avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Yu, Qiu, Long, Yang, Zhang, Xu, Chang, Du, Hou, Yu, Zeng, Wang, Sun: "A novel fully human anti-CD47 antibody as a potential therapy for human neoplasms with good safety." dans: Biochimie, Vol. 151, pp. 54-66, (2018) (PubMed).

  • Antigène
    CD47
    Autre désignation
    CD47 (CD47 Produits)
    Synonymes
    IAP Protein, MER6 Protein, OA3 Protein, 9130415E20Rik Protein, AA407862 Protein, AI848868 Protein, AW108519 Protein, B430305P08Rik Protein, Itgp Protein, CD47/IAP Protein, alkaline phosphatase, intestinal Protein, CD47 molecule Protein, CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Protein, Cd47 molecule Protein, ALPI Protein, CD47 Protein, Cd47 Protein
    Sujet
    Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
    Poids moléculaire
    40.4 kDa
    NCBI Accession
    NP_942088
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