FCGR1A
(Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A))
Type de proteíne
Recombinant
Activité biologique
Active
Attributs du protein
AA 25-297
Origine
Souris
Source
HEK-293 Cells
Purification/Conjugué
Cette FCGR1A protéine est marqué à la His tag.
Marque
MABSol®
Séquence
AA 25-297
Attributs du produit
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 31.2 kDa. The protein migrates as 40-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
FCGR1A
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
Restrictions
For Research Use only
Format
Lyophilized
Buffer
PBS, pH 7.4
Conseil sur la manipulation
Please avoid repeated freeze-thaw cycles.
Stock
-20 °C
Stockage commentaire
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Chini, Peclat, Warner, Kashyap, Espindola-Netto, de Oliveira, Gomez, Hogan, Tarragó, Puranik, Agorrody, Thompson, Dang, Clarke, Childs, Kanamori, Witte, Vidal, Kirkland, De Cecco, Chellappa et al.: "CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels. ..." dans: Nature metabolism, Vol. 2, Issue 11, pp. 1284-1304, (2020) (PubMed).
Antigène
FCGR1A
(Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A))
CD64 Protein, CD64A Protein, FCRI Protein, IGFR1 Protein, FcgammaRI Protein, Fcgr1 Protein, Fcgr1b Protein, AI323638 Protein, AV092959 Protein, IGGHAFC Protein, FCGR1A Protein, Fc fragment of IgG receptor Ia Protein, Fc receptor, IgG, high affinity I Protein, FCGR1A Protein, Fcgr1a Protein, Fcgr1 Protein
Sujet
Receptors that recognize the Fc portion of IgG are divided into three groups designated Fc gamma RI, RII, and RIII, also known respectively as CD64, CD32, and CD16. Fc gamma RI binds IgG with high affinity and functions during early immune responses. Fc gamma RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. High affinity immunoglobulin gamma Fc receptor I is also known as FCGR1A, FCG1, FCGR1, CD64 and IGFR1, is a type of integral membrane glycoprotein that binds monomeric IgG-type antibodies with high affinity, which belongs to the immunoglobulin superfamily or FCGR1 family. FCGR1A / CD64 contains 3 Ig-like C2-type (immunoglobulin-like) domains. CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells.