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CTLA4 Protein (AA 37-160) (Fc Tag)

CTLA4 Origine: Humain Hôte: HEK-293 Cells Recombinant >98 % as determined by SDS-PAGE. Active
N° du produit ABIN2180932
  • Antigène Voir toutes CTLA4 Protéines
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 37-160
    Origine
    • 31
    • 14
    • 6
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    Humain
    Source
    • 30
    • 13
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette CTLA4 protéine est marqué à la Fc Tag.
    Séquence
    AA 37-160
    Attributs du produit
    This protein carries a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 40 kDa. The predicted N-terminus is Ala 37. As a result of glycosylation, the reducing (R) protein migrates as 50-55 kDa, and the non-reducing (NR) protein migrates as 100-110 kDa in SDS-PAGE.
    Pureté
    >98 % as determined by SDS-PAGE.
    Stérilité
    0.22 μm filtered
    niveau d'endotoxine
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product CTLA4 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Conseil sur la manipulation
    Please avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Gonzalez-Nieto, Castro, Bischof, Shin, Ricciardi, Bailey, Dang, Pedreño-Lopez, Magnani, Ejima, Allison, Gil, Evans, Rakasz, Lifson, Desrosiers, Martins: "Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques." dans: PLoS pathogens, Vol. 15, Issue 9, pp. e1008015, (2019) (PubMed).

  • Antigène
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    Autre désignation
    CTLA-4 (CTLA4 Produits)
    Synonymes
    CTLA-4 Protein, CTLA4 Protein, CD152 Protein, Cd152 Protein, Ctla-4 Protein, Ly-56 Protein, CD Protein, CELIAC3 Protein, GRD4 Protein, GSE Protein, IDDM12 Protein, sCTLA4 Protein, cytotoxic T-lymphocyte associated protein 4 Protein, cytotoxic T-lymphocyte-associated protein 4 Protein, CTLA4 Protein, Ctla4 Protein
    Sujet
    CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
    Poids moléculaire
    39.9 kDa
    NCBI Accession
    NP_005205
    Pathways
    Cancer Immune Checkpoints
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