Mesothelin Protein (MSLN) (AA 296-580) (Fc Tag)
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- Antigène Voir toutes Mesothelin (MSLN) Protéines
- Mesothelin (MSLN)
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 296-580
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette Mesothelin protéine est marqué à la Fc Tag.
- Séquence
- AA 296-580
- Attributs du produit
- This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 59.6 kDa. As a result of glycosylation, the protein migrates as 60-68 kDa under reducing (R) condition, and 120-130 kDa under non-reducing (NR) condition (SDS-PAGE).
- Pureté
- >95 % as determined by SDS-PAGE.
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product MSLN Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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Preclinical evaluation of a novel anti-mesothelin immunotoxin based on a single domain antibody as the targeting ligand." dans: International journal of pharmaceutics, Vol. 602, pp. 120647, (2021) (PubMed).
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Preclinical evaluation of a novel anti-mesothelin immunotoxin based on a single domain antibody as the targeting ligand." dans: International journal of pharmaceutics, Vol. 602, pp. 120647, (2021) (PubMed).
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- Antigène
- Mesothelin (MSLN)
- Autre désignation
- Mesothelin (MSLN Produits)
- Synonymes
- MPF Protein, SMRP Protein, MSLN Protein, mesothelin Protein, MSLN Protein, Msln Protein, LOC611363 Protein, LOC100524016 Protein
- Sujet
- Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
- Poids moléculaire
- 59.1 kDa
- Pathways
- EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process
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