TNFRSF21
Origine: Humain
Hôte: Mammalian Cells
Recombinant
The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Indications d'application
This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
Restrictions
For Research Use only
Format
Liquid
Buffer
1X PBS containing 10 % glycerol
Conseil sur la manipulation
Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Stock
-80 °C
Stockage commentaire
Store in working aliquots at -70 °C.
Antigène
TNFRSF21
(Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several death receptors including DR3, DR4, DR5, and DR6 have been identified. Like TNF-R1, DR6 (also known as TNFRSF21) interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-?B and JNK. DR6 is widely expressed in human tissues and cell lines (2). Recently, DR6 was found to interact with an amino-terminal fragment of the Beta-amyloid protein (APP) in neurons, activating a caspase 6-dependent apoptotic event leading to axonal degeneration and pruning (3).