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Persephin Protein (PSPN)

PSPN Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant < 98 % by SDS-PAGE gel and HPLC analyses. Active
N° du produit ABIN2468967
  • Antigène Voir toutes Persephin (PSPN) Protéines
    Persephin (PSPN)
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    • 5
    • 2
    • 1
    Souris
    Source
    • 7
    • 1
    Escherichia coli (E. coli)
    Séquence
    ALAGSCRLWS LTLPVAELGL GYASEEKVIF RYCAGSCPQE ARTQHSLVLA RLRGRGRAHG RPCCQPTSYA DVTFLDDQHH WQQLPQLSAA ACGCGG
    Attributs du produit
    The ED50 was determined by its ability to stimulate proliferation of human thyroid carcinoma cells (TT cells) is < 0.1 ng/mL, corresponding to a specific activity of > 1 x 107 units/mg.
    Pureté
    < 98 % by SDS-PAGE gel and HPLC analyses.
    niveau d'endotoxine
    Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
    Top Product
    Discover our top product PSPN Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Conseil sur la manipulation
    As with any protein, exposing Persephin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
    Stock
    -20 °C
    Stockage commentaire
    The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted Persephin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
    Date de péremption
    24 months
  • Antigène
    Persephin (PSPN)
    Autre désignation
    Persephin (PSPN Produits)
    Synonymes
    PSPN Protein, PSP Protein, persephin Protein, PSPN Protein, Pspn Protein
    Sujet
    Persephin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFRα (α1-α4) receptors. The GFRα4 was first identified in chicken and was later shown to be the preferential binding subunit for Persephin. Persephin promotes the survival of ventral midbrain dompaminergic neurons and motor neurons after sciatic nerve oxotomy, and like GNDF, promotes ureteric bud branching. However, in contrast to GDNF and Neurturin, Persephin does not support survival of peripheral neurons. Recombinant murine Persephin is a disulfide-linked homodimer, composed of two 10.3 kDa polypeptide chains (96 total amino acid residues). Each chain contains seven conserved cysteine residues, one of which (Cys 63) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration
    ID gène
    19197
    NCBI Accession
    NP_032980
    OMIM
    247269886
    UniProt
    O70300
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