PUMA Protein (AA 76-170) (His tag,Strep II tag)
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- Antigène Voir toutes PUMA (BBC3) Protéines
- PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 76-170
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette PUMA protéine est marqué à la His tag,Strep II tag.
- Application
- Western Blotting (WB), ELISA, Mass Spectrometry (MS)
- Pureté
- ~95 %
- Top Product
- Discover our top product BBC3 Protéine
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- Indications d'application
- This recombinant protein can be used for WB, ELISA, MS.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 1X PBS containing 0.1 % SDS and 0.02 % NaN
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- Stock
- -80 °C
- Stockage commentaire
- Store in working aliquots at -70 °C.
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- Antigène
- PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
- Autre désignation
- PUMA (BBC3 Produits)
- Synonymes
- BBC3 Protein, Puma Protein, JFY-1 Protein, JFY1 Protein, PUMA Protein, PUMA/JFY1 Protein, BCL2 binding component 3 Protein, Bcl-2 binding component 3 Protein, BBC3 Protein, Bbc3 Protein, bbc3 Protein
- Sujet
- Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse (1-3). PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-? and PUMA-? (1). PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. This PUMA recombinant protein is recognized by several ProSci PUMA monoclonal antibodies, but not the two polyclonal antibodies (PSI # 3041 and 3043).
- Poids moléculaire
- 15 kDa (Calculated)
- ID gène
- 27113
- OMIM
- 56748610
- UniProt
- Q9BXH1
- Pathways
- Signalisation p53, Positive Regulation of Endopeptidase Activity
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