CD74 Protein (His tag)
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- Antigène Voir toutes CD74 Protéines
- CD74 (HLA-DR-gamma (CD74))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette CD74 protéine est marqué à la His tag.
- Application
- Western Blotting (WB), ELISA
- Attributs du produit
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Measured by its binding ability in a functional ELISA. Immobilized human CD74 at 5 μg/mL (100 μL/well ) can bind biotinylated human CTSL1 with a linear range of 3. 2 - 500 ng/mL.
- Pureté
- >95 % as determined by SDS-PAGE.
- Top Product
- Discover our top product CD74 Protéine
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- Indications d'application
- This recombinant protein can be used for WB, ELISA. For research use only.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Stock
- -80 °C,-20 °C
- Stockage commentaire
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
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- Antigène
- CD74 (HLA-DR-gamma (CD74))
- Autre désignation
- CD74 (CD74 Produits)
- Synonymes
- DHLAG Protein, HLADG Protein, II Protein, Ia-GAMMA Protein, CLIP Protein, Ii Protein, INVG34 Protein, Iclp-1 Protein, iclp1 Protein, wu:fb11f09 Protein, wu:fb12a01 Protein, wu:fb13d06 Protein, wu:fk94e07 Protein, Iclp-2 Protein, cd74 Protein, iclp2 Protein, zgc:123161 Protein, CD74 molecule Protein, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) Protein, CD74 molecule, major histocompatibility complex, class II invariant chain a Protein, CD74 molecule, major histocompatibility complex, class II invariant chain b Protein, CD74 Protein, Cd74 Protein, cd74a Protein, cd74b Protein
- Sujet
- Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.
- Poids moléculaire
- 19.3 kDa
- ID gène
- 972
- NCBI Accession
- NP_004346
- UniProt
- P04233
- Pathways
- Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
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