IL-9 Protein (AA 19-144)
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- Antigène Voir toutes IL-9 (IL9) Protéines
- IL-9 (IL9) (Interleukin 9 (IL9))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 19-144
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Origine
- Humain
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Source
- Cellules d'insectes
- Application
- Flow Cytometry (FACS)
- Pureté
- > 90 % , as determined by Coomassie stained SDS-PAGE.
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
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Less than 0.1 EU per μg of protein as determine by the LAL method.
- Top Product
- Discover our top product IL9 Protéine
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Biological activity: Human IL-9 induces proliferation of MO7e cells. ED50=0.1-0.5 ng/mL, corresponding to a specific activity of 2-10 x 106 units/mg.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Reconstitution
- For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 μg/mL in sterile buffer (PBS, HPBS, DPBS, and EBSS) containing carrier protein such as 1 % BSA or HSA. After dilution, the cytokine can be stored between 2 °C and 8 °C for one month or from -20 °C to -70 °C for up to 3 months.
- Buffer
- 0.22 μm filtered protein solution is in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- Unopened vial can be stored between 2°C and 8°C for three months, at -20°C for six months, or at -70°C for one year.
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- Antigène
- IL-9 (IL9) (Interleukin 9 (IL9))
- Autre désignation
- IL-9 (IL9 Produits)
- Synonymes
- IL9 Protein, IL-9 Protein, Il-9 Protein, P40 Protein, HP40 Protein, interleukin 9 Protein, IL9 Protein, il9 Protein, Il9 Protein
- Sujet
- IL-9 was initially identified in mice as a T cell growth factor. Human and murine IL-9 show a 56 % amino acid sequence homology. IL-9 is a cytokine that acts as a regulator of a variety of hematopoietic cells, stimulates cell proliferation, and prevents apoptosis. The IL-9 receptor consists of the cytokine-specific IL-9 receptor α-chain (IL-9Rα ) and the common γ-chain that is shared by IL-2, IL-4, IL-7, IL-15, and IL-21. IL-9 is expressed by activated Th9, Th17, Tregs, and mast cells and appears to play an important role in the development and function of subsets within the CD4+ T cell lineage. IL-9 also inhibits immune responses by enhancing the suppressive properties of Tregs and by recruiting immunosuppressive mast cells to sites of inflammation. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a key factor in the pathogenesis of bronchial hyperresponsiveness. In this sense, it has been described that IL-9 and IL-9R expression are increased in lungs of asthmatic patients. In addition, IL-9 promotes mast cell mediated intestinal permeability and plays a role in the development of food allergies. IL-9 has also been associated with atopic dermatitis.
- Poids moléculaire
- The 126 amino acid recombinant protein has a predicted molecular mass of approximately 14 kDa. The protein migrates as multiple bands with the molecular mass of 18 - 25 kDa band in SDS-PAGE in DTT-reducing conditions due to different glycosylation. The N-
- Pathways
- Signalistation JAK/STAT
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