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CCL23 Protein (AA 46-120)

CCL23 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 98 % , as determined by Coomassie stained SDS-PAGE. FACS Active
N° du produit ABIN2666897
  • Antigène Voir toutes CCL23 Protéines
    CCL23 (Chemokine (C-C Motif) Ligand 23 (CCL23))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 46-120
    Origine
    • 9
    • 2
    • 1
    Humain
    Source
    • 7
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Application
    Flow Cytometry (FACS)
    Pureté
    > 98 % , as determined by Coomassie stained SDS-PAGE.
    Stérilité
    0.22 μm filtered
    niveau d'endotoxine

    Less than 0.01 ng per μg cytokine as determined by the LAL method.

    Top Product
    Discover our top product CCL23 Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Commentaires

    Biological activity: Bioactivity was measured by its property to chemoattract THP-1 cells in a dose dependent manner.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Reconstitution
    For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 μg/mL in sterile buffer (PBS, HPBS, DPBS, and EBSS) containing carrier protein such as 1 % BSA or HSA. After dilution, the cytokine can be stored between 2 °C and 8 °C for one month or from -20 °C to -70 °C for up to 3 months.
    Buffer
    0.22 μm filtered protein solution is in PBS.
    Conseil sur la manipulation
    Avoid repeated freeze/thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    Unopened vial can be stored between 2°C and 8°C for three months, at -20°C for six months, or at -70°C for one year.
  • Antigène
    CCL23 (Chemokine (C-C Motif) Ligand 23 (CCL23))
    Autre désignation
    CCL23 (CCL23 Produits)
    Synonymes
    CK-BETA-8 Protein, CKb8 Protein, Ckb-8 Protein, Ckb-8-1 Protein, MIP-3 Protein, MIP3 Protein, MPIF-1 Protein, SCYA23 Protein, hmrp-2a Protein, C-C motif chemokine 23 Protein, C-C motif chemokine ligand 23 Protein, chemokine (C-C motif) ligand 23 Protein, LOC508666 Protein, CCL23 Protein
    Sujet
    Human CCL23 was initially identified in a cDNA library derived from human endothelial cells. CCL23 has six cysteine residues and posseses a separately encoded amino-terminal domain, characteristic of similar chemokines CCL6, CCL9, and CCL15. These four chemokines are weak agonists for CCR1, nevertheless, they can be proteolytically cleaved in the amino-terminus, resulting in forms with higher chemoattractant activity. Thus, NH2-terminus truncated forms of CCL23 have been detected in synovial fluid of patients with rheumatoid arthritis (RA). In vitro studies have shown that CCL23 can be processed by MMPs at the amino and carboxyl terminus. CCL23 (26-99) is the predominant stable form after using MMP1, 2, 3, 7, 8, or 12. CCL23 (30-99) is formed by MMP14, elastase, and proteolytic activity in arthritic synovial fluid. In addition, CCL23 has been detected in serum of patients with active RA, in conjunction with CXCL13, TNFSR9, M-CSF, and TNFα. High levels in serum of these cytokines correlate with joint inflammation and have been considered as biomarkers of active RA. Also, high levels of CCL23 have been detected in plasma of atherosclerotic patients. High expression of CCL23 has been found in skin of atopic dermatitis patients, and in mucosal epithelial cells and inflammatory cells in sinonasal tissues of patients with chronic rhinosinusitis (CRS).
    Poids moléculaire
    The 75 amino acid recombinant protein has a predicted molecular mass of approximately 8.5 kDa. The DTT-reduced and non-reduced protein migrate at approximately 12 and 14 kDa by SDS-PAGE respectively. The N-terminal amino acid is Arg.
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