FGF8 Protein (AA 23-215, N-Term)
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- Antigène Voir toutes FGF8 Protéines
- FGF8 (Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 23-215, N-Term
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Application
- Flow Cytometry (FACS)
- Pureté
- >97 % , as determined by Coomassie stained SDS-PAGE gel and HLPC analysis.
- niveau d'endotoxine
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Less than 0.1 ng per μg of protein.
- Top Product
- Discover our top product FGF8 Protéine
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Biological activity: ED50 = 2.0 - 4.0 ng/ml, corresponding to a specific activity of 2.5 - 5.0 x 105 units/mg,as measured by its ability to stimulate proliferation of BALB/c 3T3 cells in a dose dependent manner.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer, such as 5 % Trehalose, and store working aliquots at -20 °C to -80 °C.
- Buffer
- Lyophilized, carrier-free.
- Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- Unopened vial can be stored at -20°C or -70°C.
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- Antigène
- FGF8 (Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8))
- Autre désignation
- FGF-8 (FGF8 Produits)
- Synonymes
- Aigf Protein, Fgf-8 Protein, AIGF Protein, FGF-8 Protein, HBGF-8 Protein, HH6 Protein, KAL6 Protein, fibroblast growth factor 8 Protein, Fgf8 Protein, FGF8 Protein
- Sujet
- FGF-8 belongs to the fibroblast growth factor (FGF) family and plays an important role in cell growth, embryogenesis, and tumorigenesis. Four isoforms (a, b, e, and f) of human FGF-8 generated by alternative splicing of the mRNA have been described. The isoforms may have different functions during embryogenesis. During prenatal stages, FGF-8 is required for the normal development of various organs, including limbs and central nervous system. FGF-8 was first cloned from SC-3 mouse mammary carcinoma cells and was found to be induced in response to androgenic stimuli. FGF-8 is found to have a transforming capacity and is detected in human prostate and breast carcinoma specimens and cell lines. The isoform FGF-8b has the highest affinity to FGF receptors and the strongest transforming capacity.
- Poids moléculaire
- The 194 amino acid recombinant protein has a predicted molecular mass of approximately 22.5 kDa. The predicted N-terminal amino acid is Met.
- Pathways
- Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis
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