Thrombopoietin Protein (THPO) (AA 22-195)
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- Antigène Voir toutes Thrombopoietin (THPO) Protéines
- Thrombopoietin (THPO)
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 22-195
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Application
- Flow Cytometry (FACS)
- Pureté
- >98 % , as determined by Coomassie stained SDS-PAGE and HPLC analysis.
- niveau d'endotoxine
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Less than 0.1 ng per μg of protein.
- Top Product
- Discover our top product THPO Protéine
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Biological activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1.0 x 106 units/mg.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer, such as 5 % Trehalose, and store working aliquots at -20 °C to -80 °C.
- Buffer
- Lyophilized, carrier-free.
- Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- Unopened vial can be stored at -20°C or -70°C.
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- Antigène
- Thrombopoietin (THPO)
- Autre désignation
- Thrombopoietin (THPO Produits)
- Synonymes
- MGDF Protein, MKCSF Protein, ML Protein, MPLLG Protein, THCYT1 Protein, TPO Protein, Mgdf Protein, Ml Protein, Mpllg Protein, Tpo Protein, Tpo1 Protein, Tpo2 Protein, Tpo3 Protein, Tpo4 Protein, tpo Protein, LOC100231762 Protein, thrombopoietin Protein, THPO Protein, Thpo Protein, thpo Protein
- Sujet
- TPO is a key regulator of megakaryocytopoiesis and thrombopoiesis. It signals through the c-mpl receptor and stimulates the proliferation and maturation of megakaryocytes, hence, TPO plays an important role in regulating the level of circulating platelets in vivo. It has also been shown that TPO is able to promote the survival, self-renewal, and expansion of hematopoietic stem cells and primitive multilineage progenitors. Besides its hematopoietic effects, TPO is expressed in the brain where it promotes apoptosis of hypoxia sensitized neurons and inhibits neuronal differentiation by blocking NGF-induced signaling.
- Poids moléculaire
- The 174 amino acid recombinant protein has a predicted molecular mass of approximately 18.6 kDa. The predicted N-terminal amino acid is Ser.
- Pathways
- Signalistation JAK/STAT, Hormone Activity
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