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IL12 Protein (C-Term, Extracellular Domain)

IL12 Origine: Humain Hôte: HEK-293T Cells Recombinant > 95 %, as determined by SDS-PAGE Active
N° du produit ABIN1684636
  • Antigène Voir toutes IL12 Protéines
    IL12 (Interleukin 12 (IL12))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    C-Term, Extracellular Domain
    Origine
    • 19
    • 11
    • 4
    • 1
    Humain
    Source
    • 14
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    HEK-293T Cells
    Specificité
    DNA sequence encoding extracellular domain of Human IL-12B fused to a C-terminal polyHis tag was expressed in HEK cells.
    Attributs du produit
    Recombinant Human Interleukin-12B p40 subunit is a monomer consisting of 306 amino acid residue and migrates as an approximately 46 kDa protein under reducing conditions in SDS-PAGE.
    Pureté
    > 95 %, as determined by SDS-PAGE
    Stérilité
    0.2 μm filtered
    niveau d'endotoxine
    Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
    Top Product
    Discover our top product IL12 Protéine
  • Commentaires

    The activity was determined by its ability to bind recombinant Human IL-12RB1 in functional ELISA. Protein Sequence 10 0 30 40 50 60 MCHQQLVISW FSLVFLASPL VAIWELKKDV YVVELDWYPD APGEMVVLTC DTPEEDGITW 70 80 90 100 110 120 TLDQSSEVLG SGKTLTIQVK EFGDAGQYTC HKGGEVLSHS LLLLHKKEDG IWSTDILKDQ 130 140 150 160 170 180 KEPKNKTFLR CEAKNYSGRF TCWWLTTIST DLTFSVKSSR GSSDPQGVTC GAATLSAERV 190 00 10 20 30 40 RGDNKEYEYS VECQEDSACP AAEESLPIEV MVDAVHKLKY ENYTSSFFIR DIIKPDPPKN 50 60 70 80 90 300 LQLKPLKNSR QVEVSWEYPD TWSTPHSYFS LTFCVQVQGK SKREKKDRVF TDKTSATVIC 310 320 330 RKNASISVRA QDRYYSSSWS EWASVPCS. Complete precursor sequence shown, expressed chain highlighted

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
    Buffer
    PBS solution pH 7.4.
    Conseil sur la manipulation
    Avoid repeated freeze/thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    The lyophilized antibody is stable for at least 1 year from date of receipt at -20 °C. Upon reconstitution, this antibody can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months without detectable loss of activity.
    Date de péremption
    12 months
  • Antigène
    IL12 (Interleukin 12 (IL12))
    Autre désignation
    IL-12 (IL12 Produits)
    Synonymes
    CLMF Protein, CLMF2 Protein, IL-12B Protein, NKSF Protein, NKSF2 Protein, p40 Protein, Il-12b Protein, Il12p40 Protein, Il-12p40 Protein, Il12 Protein, IL-12p40 Protein, IL-12 Protein, LOC100217488 Protein, IL-12p35 Protein, Il-12a Protein, Ll12a Protein, p35 Protein, IL12p40 Protein, IL12B Protein, IL-12 p35 Protein, interleukin 12B Protein, interleukin 12A Protein, interleukin 12b Protein, interleukin 12a Protein, Interleukin 12 level Protein, IL12B Protein, IL12A Protein, Il12b Protein, Il12a Protein, IL12 Protein, il12a Protein
    Sujet
    IL-6 is produced by many different cell types. The main sources in vivo are stimulated monocytes, fibroblasts, and endothelial cells. Macrophages, T-cells and B-lymphocytes, granulocytes, smooth muscle cells, eosinophils, chondrocytes, osteoblasts, mast cells, glial cells, and keratinocytes also produce IL6 after stimulation. IL6 is a member of a family of cytokines, which also includes LIF, CNTF, Oncostatin M, IL11, and CT-1. All known members of the IL6 cytokine family induce hepatic expression of acute phase proteins. The IL6 receptor is expressed on T-cells, mitogen-activated B-cells, peripheral monocytes and some macrophage- and B-cell derived tumor cell types. It is not expressed in resting B-cells but in resting T-cells. The IL6 receptor is a strongly glycosylated protein of 80 kDa and a length of 449 amino acids. It has been designated CD126.
    UniProt
    P29460
    Pathways
    Signalistation JAK/STAT, Signalisation TLR, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
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