LIM Domain Kinase 1 Protein (LIMK1) (Myc-DYKDDDDK Tag)
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- Antigène Voir toutes LIM Domain Kinase 1 (LIMK1) Protéines
- LIM Domain Kinase 1 (LIMK1)
- Type de proteíne
- Recombinant
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette LIM Domain Kinase 1 protéine est marqué à la Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Attributs du produit
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- Recombinant human LIMK1 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product LIMK1 Protéine
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- Indications d'application
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Commentaires
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Stock
- -80 °C
- Stockage commentaire
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Antigène
- LIM Domain Kinase 1 (LIMK1)
- Autre désignation
- Limk1 (LIMK1 Produits)
- Synonymes
- limk1 Protein, xlimk1 Protein, GB16654 Protein, LIMK1 Protein, LIMK Protein, LIMK-1 Protein, LIM domain kinase 1 Protein, LIM domain kinase 1a Protein, LIM domain kinase 1 L homeolog Protein, LIM-domain containing, protein kinase Protein, LIMK1 Protein, limk1a Protein, limk1 Protein, CpipJ_CPIJ000717 Protein, LOC413152 Protein, Limk1 Protein, limk1.L Protein
- Sujet
- There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011].
- Poids moléculaire
- 72.4 kDa
- NCBI Accession
- NP_002305
- Pathways
- Caspase Cascade in Apoptosis, Regulation of Cell Size, CXCR4-mediated Signaling Events
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