Patched 1 Protein (PTCH1) (DYKDDDDK Tag)

N° du produit ABIN2712353

Détail du produit

Antigène: Patched 1 (PTCH1)

Type de proteíne: Recombinant

Origine: Humain

Source: Insect cells (Sf9)

Purification/Conjugué: Cette Patched 1 protéine est marqué à la DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human PTCH1 (C-term DDK tag, transcript variant 1b) protein expressed in Sf9 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 50 mM Tris-HCl, pH 8.0, 100 mM glycine, 10 % glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: Patched 1 (PTCH1)

Autre désignation: Ptch1 (PTCH1 Produits)

Synonymes: BCNS Protein, HPE7 Protein, NBCCS Protein, PTC Protein, PTC1 Protein, PTCH Protein, PTCH11 Protein, lep Protein, ptc1 Protein, ptc2 Protein, Ptch Protein, Ptch2 Protein, Ptc-1 Protein, XPtc1 Protein, patched Protein, patched1 Protein, A230106A15Rik Protein, Ptc Protein, Ptc1 Protein, mes Protein, patched 1 Protein, patched 1 L homeolog Protein, Protein patched homolog 1 Protein, PTCH1 Protein, ptch1 Protein, Ptch1 Protein, ptch1.L Protein, ptc-1 Protein

Sujet: This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

Poids moléculaire: 30.4 kDa

NCBI Accession: NP_000255

Pathways: Signalisation Hedgehog, Carbohydrate Homeostasis, Tube Formation