CBFA2T2 Protein (Transcript Variant 4) (Myc-DYKDDDDK Tag)
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- Antigène Voir toutes CBFA2T2 Protéines
- CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
- Type de proteíne
- Recombinant
- Attributs du protein
- Transcript Variant 4
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette CBFA2T2 protéine est marqué à la Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Attributs du produit
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- Recombinant human CBFA2T2 (transcript variant 4) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product CBFA2T2 Protéine
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- Indications d'application
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Commentaires
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Stock
- -80 °C
- Stockage commentaire
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Antigène
- CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
- Autre désignation
- Cbfa2t2 (CBFA2T2 Produits)
- Synonymes
- MTGR1 Protein, A430091M07 Protein, C330013D05Rik Protein, Cbfa2t2h Protein, EHT Protein, ZMYND3 Protein, p85 Protein, XETOR Protein, cbfa2t2-a Protein, CBFA2/RUNX1 translocation partner 2 Protein, core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) Protein, CBFA2/RUNX1 translocation partner 2 L homeolog Protein, Cbfa2t2 Protein, CBFA2T2 Protein, cbfa2t2.L Protein
- Sujet
- In acute myeloid leukemia, especially in the M2 subtype, the t(821)(q22q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5&apos-region of the RUNX1 (AML1) gene fused to the 3&apos-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
- Poids moléculaire
- 63.7 kDa
- NCBI Accession
- NP_001034798
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