ERCC1 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- Antigène Voir toutes ERCC1 Protéines
- ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))
- Type de proteíne
- Recombinant
- Attributs du protein
- Transcript Variant 1
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette ERCC1 protéine est marqué à la Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Attributs du produit
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- Recombinant human ERCC1 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product ERCC1 Protéine
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- Indications d'application
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Commentaires
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Stock
- -80 °C
- Stockage commentaire
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Antigène
- ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))
- Autre désignation
- Ercc1 (ERCC1 Produits)
- Synonymes
- COFS4 Protein, RAD10 Protein, UV20 Protein, Ercc-1 Protein, ercc1 Protein, T12H1.18 Protein, T12H1_18 Protein, UV REPAIR DEFICIENT 7 Protein, UVR7 Protein, ERCC excision repair 1, endonuclease non-catalytic subunit Protein, excision repair cross-complementing rodent repair deficiency, complementation group 1 Protein, DNA excision repair protein ERCC-1 Protein, nucleotide repair protein Protein, excision repair cross-complementation group 1 L homeolog Protein, excision repair cross-complementation group 1 Protein, ERCC1 Protein, Ercc1 Protein, CC1G_04546 Protein, CpipJ_CPIJ013903 Protein, PITG_13719 Protein, ercc1 Protein, ercc1.L Protein
- Sujet
- The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
- Poids moléculaire
- 35.4 kDa
- NCBI Accession
- NP_973730
- Pathways
- Réparation de l'ADN, Production of Molecular Mediator of Immune Response
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