HAAO Protein (Myc-DYKDDDDK Tag)
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- Antigène Voir toutes HAAO Protéines
- HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))
- Type de proteíne
- Recombinant
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette HAAO protéine est marqué à la Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Attributs du produit
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- Recombinant human HAAO protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product HAAO Protéine
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- Indications d'application
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Commentaires
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Stock
- -80 °C
- Stockage commentaire
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Antigène
- HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))
- Autre désignation
- Haao (HAAO Produits)
- Synonymes
- Afu2g17450 Protein, 0610007K21Rik Protein, 0610012J07Rik Protein, 3-HAO Protein, 3-HAOxase Protein, 3HAO Protein, zgc:103585 Protein, HAO Protein, 3-hydroxyanthranilate 3,4-dioxygenase Protein, 3-hydroxyanthranilate 3,4-dioxygenase L homeolog Protein, SPO1774 Protein, CNB05620 Protein, AFUA_2G17450 Protein, Bcep18194_C7641 Protein, Kfla_5491 Protein, Micau_4935 Protein, RBRH_03005 Protein, Krodi_1278 Protein, haao Protein, HAAO Protein, Haao Protein, haao.L Protein
- Sujet
- 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.
- Poids moléculaire
- 32.4 kDa
- NCBI Accession
- NP_036337
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