PRDM16 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- Antigène Voir toutes PRDM16 Protéines
- PRDM16 (PR Domain Containing 16 (PRDM16))
- Type de proteíne
- Recombinant
- Attributs du protein
- Transcript Variant 1
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette PRDM16 protéine est marqué à la Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Attributs du produit
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- Recombinant human PRDM16 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product PRDM16 Protéine
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- Indications d'application
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Commentaires
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Stock
- -80 °C
- Stockage commentaire
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Antigène
- PRDM16 (PR Domain Containing 16 (PRDM16))
- Autre désignation
- Prdm16 (PRDM16 Produits)
- Synonymes
- PRDM16 Protein, wu:fc09g08 Protein, MEL1 Protein, PFM13 Protein, 5730557K01Rik Protein, C130091E20 Protein, csp1 Protein, mKIAA1675 Protein, mel1 Protein, PR/SET domain 16 Protein, PR domain containing 16 Protein, PRDM16 Protein, prdm16 Protein, Prdm16 Protein
- Sujet
- The reciprocal translocation t(13)(p36q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
- Poids moléculaire
- 140.1 kDa
- NCBI Accession
- NP_071397
- Pathways
- Stem Cell Maintenance, Brown Fat Cell Differentiation
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