Presenilin 1 Protein (PSEN1) (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- Antigène Voir toutes Presenilin 1 (PSEN1) Protéines
- Presenilin 1 (PSEN1)
- Type de proteíne
- Recombinant
- Attributs du protein
- Transcript Variant 1
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette Presenilin 1 protéine est marqué à la Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Attributs du produit
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- Recombinant human Presenilin-1 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product PSEN1 Protéine
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- Indications d'application
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Commentaires
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Stock
- -80 °C
- Stockage commentaire
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Antigène
- Presenilin 1 (PSEN1)
- Autre désignation
- Presenilin-1 (PSEN1 Produits)
- Synonymes
- pre1 Protein, psen Protein, zfPS1 Protein, zf-PS1 Protein, ad3 Protein, fad Protein, ps1 Protein, s182 Protein, X-PS-beta Protein, X-PS-alpha Protein, AD3 Protein, FAD Protein, PS-1 Protein, PS1 Protein, S182 Protein, Ad3h Protein, presenilin 1 Protein, presenilin 1 L homeolog Protein, psen1 Protein, PSEN1 Protein, Psen1 Protein, psen1.L Protein
- Sujet
- Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
- Poids moléculaire
- 52.5 kDa
- NCBI Accession
- NP_000012
- Pathways
- Signalisation Notch, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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