SHP1 Protein (Transcript Variant 1) (His tag)
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- Antigène Voir toutes SHP1 (PTPN6) Protéines
- SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))
- Type de proteíne
- Recombinant
- Attributs du protein
- Transcript Variant 1
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette SHP1 protéine est marqué à la His tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Attributs du produit
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- Recombinant human PTPN6 (transcript variant 1) protein expressed in E. coli.
- Produced with end-sequenced ORF clone
- Pureté
- > 95 % as determined by SDS-PAGE and Coomassie blue staining
- niveau d'endotoxine
- < 0.1 EU per μg protein as determined by LAL test
- Top Product
- Discover our top product PTPN6 Protéine
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- Indications d'application
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Commentaires
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The tag is located at the N-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris-HCl, 2 mM ß-ME, 1 mM EDTA, 1 mM DTT, 20 % Glycerol, pH 7.5. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
- Stock
- -80 °C
- Stockage commentaire
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Antigène
- SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))
- Autre désignation
- Ptpn6 (PTPN6 Produits)
- Synonymes
- HCPH Protein, HPTP1C Protein, PTP-1C Protein, SH-PTP1 Protein, SHP-1 Protein, SHP-1L Protein, SHP1 Protein, DRPLA Protein, Hcph Protein, Ptp1C Protein, me Protein, motheaten Protein, Ptph6 Protein, Shp-1 Protein, fj22f05 Protein, wu:fj22f05 Protein, zgc:55501 Protein, ptpn6 Protein, protein tyrosine phosphatase, non-receptor type 6 Protein, protein tyrosine phosphatase, non-receptor type 6 L homeolog Protein, PTPN6 Protein, Ptpn6 Protein, ptpn6 Protein, ptpn6.L Protein
- Sujet
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
- Poids moléculaire
- 35.4 kDa
- NCBI Accession
- NP_002822
- Pathways
- Signalistation JAK/STAT, TCR Signaling, Signalisation TLR, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling
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