PTTG1 Protein (Myc-DYKDDDDK Tag)
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- Antigène Voir toutes PTTG1 Protéines
- PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))
- Type de proteíne
- Recombinant
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette PTTG1 protéine est marqué à la Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Attributs du produit
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- Recombinant human Securin / PTTG1 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product PTTG1 Protéine
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- Indications d'application
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Commentaires
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Stock
- -80 °C
- Stockage commentaire
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Antigène
- PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))
- Autre désignation
- Securin,pttg1 (PTTG1 Produits)
- Synonymes
- EAP1 Protein, HPTTG Protein, PTTG Protein, TUTR1 Protein, PTTG1 Protein, securin Protein, AW555095 Protein, C87862 Protein, Pttg Protein, Pttg3 Protein, Securin Protein, Protein Cut2 Protein, pituitary tumor-transforming 1 Protein, pituitary tumor-transforming gene 1 Protein, securin, sister chromatid separation inhibitor Protein, PTTG1 Protein, Pttg1 Protein, cut2 Protein
- Sujet
- The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene.
- Poids moléculaire
- 21.8 kDa
- NCBI Accession
- NP_004210
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