STAM Protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2732750

Détail du produit

Antigène: STAM (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette STAM protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human STAM1 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: STAM (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM))

Autre désignation: Stam1 (STAM Produits)

Synonymes: STAM-1 Protein, STAM1 Protein, wu:fv75b10 Protein, zgc:55725 Protein, RGD1564499 Protein, signal transducing adaptor molecule Protein, signal transducing adapter molecule 1 Protein, Signal transducing adapter molecule 1 Protein, signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 Protein, STAM Protein, CpipJ_CPIJ003516 Protein, Tsp_03939 Protein, stam-1 Protein, Stam Protein, stam Protein

Sujet: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. [UniProtKB/Swiss-Prot Function]

Poids moléculaire: 59 kDa

NCBI Accession: NP_003464

Pathways: EGFR Signaling Pathway, EGFR Downregulation