VHL Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- Antigène Voir toutes VHL Protéines
- VHL (Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
- Type de proteíne
- Recombinant
- Attributs du protein
- Transcript Variant 1
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette VHL protéine est marqué à la Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Attributs du produit
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- Recombinant human VHL (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product VHL Protéine
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- Indications d'application
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Commentaires
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Stock
- -80 °C
- Stockage commentaire
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Antigène
- VHL (Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
- Autre désignation
- Vhl (VHL Produits)
- Synonymes
- HRCA1 Protein, RCA1 Protein, VHL1 Protein, pVHL Protein, BcDNA:RH61560 Protein, CG13221 Protein, DVhl Protein, Dmel\\CG13221 Protein, Dvhl Protein, VHL Protein, d-VHL Protein, d-vhl Protein, dVHL Protein, dmVHL Protein, vhl Protein, rca1 Protein, vhl1 Protein, hrca1 Protein, zgc:158722 Protein, Vhlh Protein, von Hippel-Lindau tumor suppressor Protein, von Hippel-Lindau Protein, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase Protein, von Hippel-Lindau disease tumor suppressor Protein, VHL Protein, Vhl Protein, vhl Protein, CpipJ_CPIJ009992 Protein
- Sujet
- Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
- Poids moléculaire
- 24 kDa
- NCBI Accession
- NP_000542
- Pathways
- Tube Formation, Signaling Events mediated by VEGFR1 and VEGFR2, Ubiquitin Proteasome Pathway
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