ZIC2 Protein (ZIC2) (Myc-DYKDDDDK Tag)

N° du produit ABIN2735883

Détail du produit

Antigène: ZIC2

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette ZIC2 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human ZIC2 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: ZIC2

Autre désignation: Zic2 (ZIC2 Produits)

Synonymes: HPE5 Protein, Ku Protein, cb851 Protein, fb26a03 Protein, wu:fb26a03 Protein, zic2 Protein, zic2.1 Protein, hpe5 Protein, hm:zeh0655 Protein, id:ibd5017 Protein, zic2.2 Protein, zic2l Protein, Zic family member 2 Protein, zinc finger protein of the cerebellum 2 Protein, zic family member 2 (odd-paired homolog, Drosophila), a Protein, Zic family member 2 L homeolog Protein, zic family member 2 (odd-paired homolog, Drosophila) b Protein, ZIC2 Protein, Zic2 Protein, zic2a Protein, zic2.L Protein, zic2b Protein

Sujet: Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos. [UniProtKB/Swiss-Prot Function]

Poids moléculaire: 54.8 kDa

NCBI Accession: NP_009060

Pathways: Tube Formation