FNDC5
(Fibronectin Type III Domain Containing 5 (FNDC5))
Type de proteíne
Recombinant
Attributs du protein
Extracellular Domain, AA 29-149
Origine
Humain, Souris, Rat
Source
Escherichia coli (E. coli)
Application
SDS-PAGE (SDS)
Réactivité croisée
Humain, Souris, Rat (Rattus)
Attributs du produit
FNDC5 (extracellular domain, human (aa 32-152) / mouse (aa 29-149)) is untagged. FNDC5 extracellular domain has 100 % identity between human, mouse and rat.
FRCP2 Protein, irisin Protein, 1500001L03Rik Protein, AI836596 Protein, C87088 Protein, PeP Protein, Pxp Protein, fndc5 Protein, si:dkey-264p5.1 Protein, zgc:158684 Protein, fibronectin type III domain containing 5 Protein, fibronectin type III domain containing 5b Protein, FNDC5 Protein, Fndc5 Protein, fndc5b Protein
Sujet
Irisin is a recently described exercise and PGC1-alpha-induced myokine secreted by skeletal muscle in mice and humans. Irisin has been shown to induce browning of white adipose tissue, but this role has been questioned and a new function in the control of mass and strength of cortical bone has been reported. The membrane fibronectin type III domain containing protein 5 (FNDC5) can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human).