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AADAT Protein (His tag)

AADAT Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant >97 % (SDS-PAGE) SDS
N° du produit ABIN2745733
  • Antigène Voir toutes AADAT Protéines
    AADAT (Aminoadipate Aminotransferase (AADAT))
    Type de proteíne
    Recombinant
    Origine
    • 6
    • 1
    • 1
    • 1
    Humain
    Source
    • 3
    • 2
    • 2
    • 2
    Escherichia coli (E. coli)
    Purification/Conjugué
    Cette AADAT protéine est marqué à la His tag.
    Application
    SDS-PAGE (SDS)
     Réactivité croisée
    Humain
    Attributs du produit
    Human full-length KAT II is fused at the N-terminus to a His-tag.
    Pureté
    >97 % (SDS-PAGE)
    Top Product
    Discover our top product AADAT Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In 50 mM phosphate buffer pH 8.0, containing 50 mM sodium chloride and 40μM pyridoxal 5'-phosphate (PLP).
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Short Term Storage: -20°C
    Long Term Storage: -80°C
    Stable for at least 6 months after receipt when stored at -80°C.
    Date de péremption
    6 months
  • Antigène
    AADAT (Aminoadipate Aminotransferase (AADAT))
    Autre désignation
    Kynurenine Aminotransferase II (AADAT Produits)
    Synonymes
    KAT2 Protein, KATII Protein, AI875679 Protein, Aadt Protein, Kat2 Protein, mKat-2 Protein, MGC80030 Protein, kat2 Protein, katii Protein, aminoadipate aminotransferase Protein, aminoadipate aminotransferase S homeolog Protein, AADAT Protein, Aadat Protein, aadat.S Protein, aadat Protein
    Sujet
    Kynurenine aminotransferases (KATs) are pyridoxal-5'-phosphate-dependent enzymes that catalyze the conversion of L-kynurenine into kynurenic acid, a neuroactive metabolite whose unbalancing is associated with a number of brain disorders. Biochemical and structural investigations revealed that L-kynurenine (L-KYN) recognition by hKAT II is achieved by exploiting structural features that are peculiar of this isoform, thus offering the possibility to select/design inhibitor molecules specifically targeting hKAT II to be used as modulators of kynurenic acid synthesis in the CNS. hKAT II is one of the aminotransferases involved in the pyridoxal 5'-phosphate (PLP)-dependent irreversible transamination of L-kynurenine (L-KYN) to kynurenic acid (KYNA) in the central nervous system. When assayed in vitro the protein also displays beta-elimination activity.
    Poids moléculaire
    ~49.8kDa
    NCBI Accession
    NP_872603
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