Profilin Protein (PFN) (AA 1-163)

N° du produit ABIN2745816

Détail du produit

Antigène: Profilin (PFN)

Type de proteíne: Recombinant

Attributs du protein: AA 1-163

Origine: Souris

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Réactivité croisée: Souris

Attributs du produit: Recombinant profilin (Toxoplasma gondii) (aa 1-163).

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.01EU/μg purified protein (LAL test, Lonza).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with 100 μL sterile water.

Concentration: Lot specific

Buffer: Lyophilized. Contains PBS.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Détail du antigène

Antigène: Profilin (PFN)

Autre désignation: Profilin (PFN Produits)

Synonymes: LOC406154 Protein, GB13380 Protein, profilin Protein, PFN Protein, PRF Protein

Sujet: TLR11, an innate sensor for profilin (Toxoplasma gondii), is an intracellular receptor that resides in the endoplasmic reticulum. The 12 membrane-spanning endoplasmic reticulum-resident protein UNC93B1 interacts directly with TLR11 and regulates the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12, a previously uncharacterized TLR, also recognizes profilin from Toxoplasma gondii. TLR12 is sufficient for recognition of profilin by plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both required in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice succumb rapidly to T. gondii infection.

Poids moléculaire: ~20kDa (SDS-PAGE)

UniProt: Q58NA1