EPH Receptor A6 Protein (Epha6)

N° du produit ABIN2746574

Détail du produit

Antigène: EPH Receptor A6 (Epha6)

Type de proteíne: Recombinant

Origine: Humain, Souris, Rat

Source: Escherichia coli (E. coli)

Application: Western Blotting (WB), Positive Control (PC)

Fonction: Purified Protein in ready-to-use SDS sample buffer.

Purification: Purified Protein

Information d'application

Indications d'application: The sample is in ready-to-use buffer for application in SDS-PAGE and Western blotting.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: For 5 applications, volume varies from 100-200 μL in reduced SDS-PAGE sample buffer.

Stock: -20 °C

Stockage commentaire: -20 °C for long term storage

Détail du antigène

Antigène: EPH Receptor A6 (Epha6)

Autre désignation: Eprhin Receptor A6 (Epha6 Produits)

Synonymes: EPHA6 Protein, Ehk2 Protein, Hek12 Protein, m-ehk2 Protein, EHK-2 Protein, EHK2 Protein, EK12 Protein, EPA6 Protein, HEK12 Protein, PRO57066 Protein, EPH receptor A6 Protein, Eph receptor A6 Protein, EPHA6 Protein, epha6 Protein, Epha6 Protein

Sujet: Ephrin A6, a member of the ephrin family, elicits biological responses in retinal neurons. It binds with high affinity to several other EphA receptors and causes growth cone collapse in retinal explants. Ephrin-A6 expression is high at embryonic day 6 (E6) and at embryonic day 8 (E8), when retinal axons grow to their tectal targets, and then this Ephrin-A6 expression gradually declines at later developmental stages. This new ephrin plays a role in the establishment of visual system topography as observed by the asymmetric distribution of ephrin-A6 in retinal cells. High levels of expression of Eph-A6 in the macula of developing human retina showed localization of Eph-A6 to (GC) ganglion cells. Eph receptors and Ephrins have indeed been implicated in multiple aspects of synaptic function, including clustering and modulating N-methyl-D-aspartate receptors, modifying the geometry of postsynaptic terminals, and influencing long-term synaptic plasticity and memory. Eph A6, in line with a number of other Eph receptors and their ephrin ligands, is involved in neural circuits of learning and memory. Genetic inhibition of the ephrin receptor (Eph A6) in knockout mice produced behavioral deficits in tests of learning and memory. The gene for EphAR6 is present on chromosome 3q11.2

Poids moléculaire: 136 kDa

NCBI Accession: NP_001073917

UniProt: B3KS12

Pathways: Signalisation RTK