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FYN Protéine

FYN Origine: Humain, Souris, Rat Hôte: Escherichia coli (E. coli) Recombinant WB, PC
N° du produit ABIN2746630
  • Antigène Voir toutes FYN Protéines
    FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))
    Type de proteíne
    Recombinant
    Origine
    Humain, Souris, Rat
    Source
    • 4
    • 3
    • 2
    • 1
    Escherichia coli (E. coli)
    Application
    Western Blotting (WB), Positive Control (PC)
    Fonction
    Purified Protein in ready-to-use SDS sample buffer.
    Purification
    Purified Protein
    Top Product
    Discover our top product FYN Protéine
  • Indications d'application
    The sample is in ready-to-use buffer for application in SDS-PAGE and Western blotting.
    Commentaires

    Synonyms: Proto-oncogene c-Fyn, p59, Src-like-kinase, SLK, Protooncogene Syn.P59-Fyn

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    For 5 applications, volume varies from 100-200 μL in reduced SDS-PAGE sample buffer.
    Stock
    -20 °C
    Stockage commentaire
    -20 °C for long term storage
  • Antigène
    FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))
    Autre désignation
    FYN (FYN Produits)
    Synonymes
    im:6908851 Protein, si:dkey-119m7.5 Protein, zgc:109996 Protein, c-fyn Protein, cfyn-a Protein, SLK Protein, SYN Protein, p59-FYN Protein, PKC Protein, fyn Protein, zgc:86720 Protein, AI448320 Protein, AW552119 Protein, FYN proto-oncogene, Src family tyrosine kinase Protein, FYN proto-oncogene, Src family tyrosine kinase S homeolog Protein, FYN proto-oncogene, Src family tyrosine kinase b Protein, FYN proto-oncogene, Src family tyrosine kinase L homeolog Protein, FYN proto-oncogene, Src family tyrosine kinase a Protein, Fyn proto-oncogene Protein, FYN Protein, fyn.S Protein, fynb Protein, fyn.L Protein, Fyn Protein, fyna Protein
    Sujet
    Protein tyrosine kinases are large multigene families which are important mediators of the signaling transduction pathways, responsible for intracellular signal transduction. Tyrosine kinases are a diverse group of cell surface transmembrane proteins that act as receptors for cytokines, growth factors, hormones and other signaling molecules. Receptor tyrosine kinases are expressed in many cell types and play important roles in a wide variety of cellular processes, including growth, differentiation, angiogenesis, metabolism and apoptosis in response to external and internal stimuli. Over-expression and/or structural alteration of tyrosine kinase family members are associated to human cancers. Tumor cells use RTK transduction pathways to achieve tumor growth, angiogenesis and metastasis making it a target in approaches of cancer therapy. Fyn kinase is a 64 kDa protein and one of the 9 members of the Src family kinase (SFK) which are important in the regulation of growth and differentiation of eukaryotic cells. Src-family kinases transduce signals that are involved in the control of a variety of cellular processes, including proliferation, differentiation, motility, and adhesion. Synthesized and N-myristoylated Fyn protein is targeted to the plasma membrane, where it is palmitoylated. Fyn encodes a membraneassociated tyrosine kinase that is implicated in the control of cell growth and it plays a key role in T-cell antigen receptor (TCR) signaling. Dually acetylated Fyn clusters in caveolae-like membrane micro domains and interacts with a variety of other signaling molecules. Fyn's biological functions are diverse and include signaling via the T cell receptor, regulation of brain function and adhesion mediated signaling. It is required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. The human Fyn gene maps to chromosome 6q21 and encodes a 537 amino acid protein.
    Poids moléculaire
    64 kDa
    UniProt
    Q96AE9
    Pathways
    Signalistation JAK/STAT, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Activated T Cell Proliferation, Thromboxane A2 Receptor Signaling
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