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IL36A/IL1F6 Protéine

IL1F6 Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE and HPLC. Func Active
N° du produit ABIN2830877
  • Antigène Voir toutes IL36A/IL1F6 (IL1F6) Protéines
    IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    • 8
    • 4
    Souris
    Source
    • 9
    • 2
    • 1
    Escherichia coli (E. coli)
    Application
    Functional Studies (Func)
    Séquence
    MNKEKELRAA SPSLRHVQDL SSRVWILQNN ILTAVPRKEQ TVPVTITLLP CQYLDTLETN RGDPTYMGVQ RPMSCLFCTK DGEQPVLQLG EGNIMEMYNK KEPVKASLFY HKKSGTTSTF ESAAFPGWFI AVCSKGSCPL ILTQELGEIF ITDFEMIVVH
    Attributs du produit
    Biological Activity: Fully biologically active when compared to standard. The specific activity determined by its ability in a functional ELISA. Immobilized rMuIL-36α at 1 μg/mL can bind recombinant murine IL-1 Rrp2 with a range of 0.15-5 μg/mL.
    Pureté
    >95 % as determined by SDS-PAGE and HPLC.
    Stérilité
    0.2 μm filtered
    Top Product
    Discover our top product IL1F6 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4, 5 % trehalose
    Stock
    -20 °C
  • Antigène
    IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))
    Autre désignation
    Il36a (IL1F6 Produits)
    Synonymes
    Il1f6 Protein, Fil1 Protein, IL-1H1 Protein, IL1RP2 Protein, Il1f9 Protein, Il36a Protein, FIL1 Protein, FIL1(EPSILON) Protein, FIL1E Protein, IL-1F6 Protein, IL1(EPSILON) Protein, IL1F6 Protein, interleukin 36, alpha Protein, interleukin 1 family, member 6 (epsilon) Protein, interleukin 1 family, member 6 Protein, interleukin 36 alpha Protein, Il36a Protein, IL1F6 Protein, IL36A Protein, Il1f6 Protein
    Sujet
    Relevance: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response, similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T cells and splenocytes. May play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c(+) alveolar macrophages. May be involved in T cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c(+) cells. May be involved in CD4(+) T cell proliferation. Induces NF-kappa B activation in macrophages. {ECO:0000269|PubMed:21860022, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23029241, ECO:0000269|PubMed:24829417}.
    Synonyms: FIL1 epsilon, IL-1 epsilon, Interleukin-1 family member 6, IL-1F6, Interleukin-1 homolog 1
    Poids moléculaire
    18.0 kDa
    UniProt
    Q9JLA2
    Pathways
    Cancer Immune Checkpoints
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