LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41 % similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. Alternative Names: LYVE-1 protein, Lymphatic Endothelial Cell protein, LYVE 1 protein, LYVE-1 protein, Lymphatic Vessel protein, LYVE1, LYVE-1, LYVE 1