This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 87.5 kDa. GP3-C5256 may be cleaved into secrete GPC3, short propeptide (aa ?-559) & Fc tag, long propeptide (aa ?-559) & Fc tag. The protein migrates as 100 kDa (secrete GPC3 & propeptide & Fc tag), 58 kDa (long propeptide & Fc tag), 40 kDa (short propeptide & Fc tag) and 35 kDa Human IgG1 Fc fragment on a SDS-PAGE gel under reducing (R) condition.
Glypican-3 (GPC3) is also known as Intestinal protein OCI-5, GTR2-2, MXR7, which belongs to the glypican family. Glypican 3 / GPC-3 is highly expressed in lung, liver and kidney. Glypican-3 inhibits the dipeptidyl peptidase activity of DPP4. Glypican-3 may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and also may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function.